Christian and Liz start their wedding preparations, and at the same time he is battling his cancer. Meanwhile, Ram trades in Kimber for a newer model, leading Kimber to go and confront Liz about her relationship with Christian.
Christian decides to employ Dr. Logan Taper for the practice, while Sean is revisited by a former client from Miami to have plastic surgery so she can attract suitors once her husband dies.
Christian relates to a patient with a unique condition whilst Sean pursues a new relationship.
A down-on-his-luck Aidan Stone (Bradley Cooper) writes a biopic about Sean and wants it to be his comeback vehicle; Kimber wants Christian to administer Botox to her daughter to enhance her chances as a baby model; a yoga instructor wants Sean and Christian to perform a procedure that they have never done before. Teddy Rowe: Katee Sackhoff. Morgan Fairchild has a cameo as herself.
Matt becomes envious of Sean and Raj bonding together. Christian and Liz give their relationship another chance. Raj's father pays a visit to see his son.
Sean tries to deal with his feelings for Julia, while Liz and Christian analyze their relationship and Christian meets someone who understands what he is experiencing with his breast cancer.
Sean tries to rejoin with his wrecked family, while Liz and Christian start getting closer as his chemotherapy begins to get him sick and Liz takes care of him.
Sean's physical and emotional well-being are greatly impacted after he makes it through Colleen's attack. Christian gets some disconcerting news.
Tragedy strikes the McNamara/Troy family after Julia learns what has caused her ill health. A visitor from Christian's past brings revealing news. Sean finds the price of fame to be more expensive than it's worth.
Sean experiences the ugly side of Hollywood in the form of a television critic. Matt experiences a special bond with one of Christian's patients. The cause of Julia's ailing health is discovered.