Sean and Christian have relocated their practice from Miami to Los Angeles. Being new to the city they find themselves having to start from scratch business wise. What they thought would naturally fall into place turns out to require some foot work. So Christian and Sean hit the town and begin discovering a whole new world.
Sean considers selling his shares of the practice to Christian and Michelle, although Michelle's past starts to threaten her future with Christian. Meanwhile, Escobar's wife needs cosmetic surgery.
Sean contrives to sell his portion of the practice; Michelle's connection with James finally ends, but not with James' boss; Gina is not happy to discover about Michelle's role in Wilbur's life; Matt tries to rekindle the spark with Kimber; and Poppy and Liz break up.
Sean drinks to a great extent as he spends a depressing Christmas without his family; Christian gets an surprising gift when a 3-year old Wilber comes back into his life; and James pressures Michelle to help as she takes forceful measures to fill her holiday kidney quota.
Even though he doubts his ability to maintain a long term relationship Christian proposes to Michelle and a lonely Sean takes a pathological case for rationalities that have as much to do with himself as with the patient, and James requires to use McNamara/Troy for her own operations.
It's the year 2026. Conor is getting the whole family together. In the present, Julia and Sean's marriage is at a crossroads.
Dr. Merrill Bobolit, who's out of jail, needs Sean's and Christian's professional services. Escobar Gallardo wants them to perform surgery on his face. And Matt tells his family that he's married and that he and his wife are expecting a baby.
Liz's new gilfriend, Poppy, wants her to have cosmetic surgery. James makes Christian and Michelle help her steal another kidney. Sean offers consultation to Marlowe, who wants longer legs.
Mrs. Grubman is back for more Plastic Surgery this time she wants Christian to preform it after she has passed on. Sean and Julia have conflicts over Conor's Surgery.
Dawn Budge needs an ear transplant. Burt Landau suffered a stroke and asks Christian and Sean to fix his face.